Arnold Herskovic, M.D., F.A.C.R., F.A.C.R.O.

Current Appointment:

Radiation Oncologist        Rush University   Medical Center Department of Radiation Oncology

Education:

1964           B.S.                                              University of Maryland,College Park, Maryland
1965           M.S.             Medical Physiology Master’s Program, West Virginia Medical Center
1969           M.D.                                                  University of Maryland,Baltimore, Maryland

Training:

1969 – 1970                Internship         Medicine
Kings County-Downstate Medical Center,
Brooklyn, New York

1970-1973                  Residency         General Radiology
New York University
Bellevue Medical Center
New York, New York

07/73 – 12/74               Residency          Radiation Therapy
Memorial Sloan-Kettering Cancer Center
New York, New York

07/74 – 12/74            Advance Career Fellow Memorial Sloan-Kettering Cancer Center
New York, New York

07/74 – 12/74            Asst. Chief Resident  Memorial Sloan-Kettering Cancer Center
New York, New York

Faculty Appointments:

01/75 – 12/75                        Instructor                       Cornell Medical School
New York, New York

Clinical Assistant Attending
Memorial Hospital
New York, New York

Assistant Radiologist
New York Hospital
New York, New York

01/76 – 06/77                        Assistant Professor         Department of Radiology (Radiation Medicine)
Los Angeles County
Southern California Cancer Center

Affiliate and Consultant Staff
California Hospital
Southern California Cancer Center
Los Angeles, California

07/77 – 12/79                        Assistant Professor         Department of Radiology
George Washington University
Washington, D.C.

01/80 – 08/82                        Assistant Professor         Department of Radiology (Radiation Oncology)
Duke University Medical Center
Durham, North Carolina

07/77 -            12/79             Assistant Professor         Department of Radiology
George Washington University
Washington, D.C.

09/82 -            07/85              Associate Professor         Radiation Oncology Center
Wayne State University
Detroit, Michigan

08/85 – 1998                         Professor                        Radiation Oncology
Wayne State University School of Medicine
Detroit, Michigan

1998 – 2005                         Adjunct Professor                       University of Minnesota

Military Service:

1970 – 1976                         Major                           U.S. Army Reserves
Retired, Honorable Discharge

 

Hospital Appointments:

09/82 – 07/91               Staff Physician
Harper Hospital
Detroit Medical Center
Department of Radiation Oncology
Detroit, Michigan

03/83 -07/91             Staff Physician  
Detroit Receiving Hospital/University Health Center
Detroit, Michigan

02/83 – Present           Consultant
Veterans Administration Hospital
Allen Park, Michigan

1983 – 1988                 Co-Chairman
Lung Committee
Southwest Oncology Group

11/82 - 07/91              Radiation Oncologist
Children’s Hospital of Michigan

1984 – 1991                Vice-Chairman
Department of Radiation Oncology
Harper-Grace Hospitals
Harper Hospital Division

1990 – 1998                 Medical Advisor
School of Radiation Technology
Wayne State Detroit)

1995 – 1999                 Radon Representative
State of Michigan Lung Cancer

1991 – 1998                 Medical Director/ Chief
Oakwood Hospital & Medical Ctr.
Department of Radiation Oncology

1992-1993                   President
Michigan Society Radiation Oncology

03/98-06/04               Medical Director
Northwest Community Hospital
Radiation Oncology
Arlington Heights, Illinois

06/04 – 06/05               Medical Staff
Allina United Hospitals
St Paul, Minnesota

06/05- present              Medical Staff
St John Medical Center
Grosse Pointe Woods & Macomb

Hospital Committees:

01/83 – 1993               Principal Investigator       Wayne State University

1983 – 1991                Principal Investigator       Radiation Therapy Oncology Group (RTOG)
WSU Radiotherapy Representative for Pediatric Oncology Group
 
1983 – 1985                 Representative                Gastrointestinal Study Group

1983 -  1991                Representative                WSU for Southwest Oncology Group

1985 – 1991                 Member                        Radioisotope Committee
Children’s Hospital of Michigan

1985 – 1991                 Member                        Radioisotope Committee
Hutzel Hospital

1985 – 1991                 Member                        Radioisotope Committee
Harper Hospital

1986 – 1992                 Member                        Human Investigation Committee
Wayne State University

1986 – 1991                 Member                        Physician Extender Committee
Harper Hospital

1991 – 1998                 Member                                    Cancer Center Committee
Oakwood Hospital

1991 – 1998                 Member                                    Radiation Safety Committee
Oakwood Hospital

1991 – 1998                 Member                                    Investigational Review Board
Oakwood Hospital
 
Membership in Professional Societies:

American Cancer Society, Fellow

American Brachytherapy Society, Fellow

American College of Radiation Oncology

American College of Radiology

American Medical Association

American Radium Society

American Society of Clinical Oncology

American Society of Therapeutic Radiology and Oncology

International Association for Study of Lung Cancer

International Endocurietherapy Society, charter member

Memorial Sloan-Kettering Cancer Center, Inc.

Michigan Medical Society

Michigan Radiological Society

Michigan Society of Therapeutic Radiologists; Served as President, Vice President & Chairman of the Board

Radiologic Society of North America

High Dose Rate Working Oncology Group, charter member

Board Certification:

1974                American Board of Radiology (Therapeutic Radiology)

 

Honors:

Fellow, American Cancer Society, 1973-1974

Fellow, American College of Radiology

Chief Resident, Memorial Hospital, July-December, 1974

Fellow American College of Radiation Oncology

National Board of Honors, 2 areas

Principal Investigator, RTOG   1983 – 1992

New York Radiologic Physics Raphex Test, 1974

Presentations in Plenary Session at ASCO, ASTRO and AAAS

- Listed in The Best Doctors in America, Fifth Edition, by Woodward/White, Inc. American registry of Outstanding Professionals, Plaque and grant from Dr Frank Jirka, former president AMA

Book Chapters:

1. Noell, K.T. and Herskovic, A.  Principles of Radiation Therapy in Central Nervous System Tumors.  In: Neurosurgery; Chapter 124.  Editors:  Wilkins and Rengachary, McGraw-Hill, Philadelphia, Pennsylvania 1984.
2. Nigro, N.D, Vaitkeviceus V.K. and Herskovic, A., Preservation of Function in the treatment of cancer of the Anus.  In:  Important Advances in Oncology: 1989.  Editors: Vincent T. Devita, Jr., Samuel Heilman and Steven A. Rosenberg, J. B. Lippincott Co., 1988.
3. 3.     Herskovic, A. , Han, I.H.,  Radiation Oncology in Colorectal and Anal Cancers. In:  Gastroenterology Clinics of North America.  W.B. Saunders, Philadelphia, Pennsylvania, 1988.
4. Rosenberg, J., Herskovic, A.M.,  Unusual Esophageal Tumors in text entitled Unusual Tumors in  the Chest  I am not sure if published
5. Herskovic, A., Kraut, Michael, Lattin, Orton, C., Byhardt, R.,Lattin, P., Han, S.  Experience with a Practical Hyperfractionated Accelerated Radiotherapy Regime.  Seminars in Radiation Oncology, Vol. 2, Nov. 1 (January) 1992; pp. 48-50.
6. Noell, K.T. and Herskovic, A.  Principles of Radiation Therapy in Central Nervous System Tumors.  In:  Neurosurgery, Chapter 124.  Editors:  Wilkins and Rengachary, McGraw-Hill, Philadelphia, Pennsylvania, 1995.
7. Noell, K.T. and Herskovic, A.  Principles of Radiation Therapy in Central Nervous System Tumors.  In:  Neurosurgery, Chapter 124.  Editors:  Wilkins and Rengachary, McGraw-Hill, Philadelphia, Pennsylvania, 2001.

 

Peer Reviewed Publications:

1. Villa Santa, U. and Herskovic A.M.  Symptomalogy of Uterine             Cervical Carcinoma.     Bulletin of the University of. Maryland.  55:3-7, 1970.
2. Blum, M., Goldberg, A., Herskovic, A.M., and Hernbert, P. Thyroid Echography.  New England Journal of Medicine., 287:1164-1169, 1972.
3. Chabora, B. McC, Lattin, P.B., Rosen, G., Chu, F.C.H. and          Herskovic, A.M.  Whole Lung Irradiation in the Pediatric Age Group: Low Dose versus Conventional Fractionation with Multi-Drug Chemotherapy. International Journal of. Radiation. Oncology. Biology and Physics., 2:465-474, 1977.
4. Ornitz, R., Herskovic, A.M., Bradley, E., Deye, J.A. and Rogers, C.C.  Clinical Observation of Early and Late Normal Tissue Injury and Tumor Control in Patients Receiving Fast Neutron Irradiation.  European Journal of Cancer, Supp., pp. 43-50, 1979.
5. Herskovic, A.M., Schaeflin, J., Kurchara, S. and Herskovic,      T.  Radiation Dose to the Eyes Using a “German Helmet” Field with the 4-MV Linear Accelerator.  Radiology, 132:486-489, 1979.
6. Herskovic, A.M., Padikal, T.N. and Lee, S.N.  Localization of Interstitial Dosimetry Utilizing the CT Scanner.  Computerized Tomography, 3:101-103, 1979.
7. Herskovic, A.M., Lee, S.N. and Padikal, T.N.  Utilization of the Computed Tomography Scanner in Interstitial Dosimetry.  Radiology, 135:781-782, 1980.
8. Ornitz, R., Herskovic, A.M., Schell, M., Fender, F. and Rogers, C.C.  Treatment Experience:  Locally Advanced Sarcomas with 15 MEV Fat Neutrons. Cancer, 45:2712-2716, 1980.M
9. Elroy, N.L., Deye, J.A. and Herskovic, A.M.  Inventory Control for 192 Ir Therapy Sources. Applied Radiology, pp. 101-103, Nov-Dec. 1980.
10. Herskovic, A.M., Heaston, D., Engler, M.J., Fishburn, R.I., Jones, R.S., Noell, K.T.  Irradiation of Biliary Carcinoma. Radiology, 139:219-222, 1981.
11. U, R., Worde, B.T., Fishburn, R.I., Noell, K.T., Woodward, K.T., Miller, L.S. and Herskovic, A.M. Hyperthermia in Cancer Treatment:  Current and Future Prospects.  Cancer and Chemotherapy, (Gan to Kagakuryoho) 9:343-356, 1982.
12. Herskovic, A.M., Ornitz, R.D., Schell, M. and Rogers, C.C. Treatment Experience – Glioblastoma Multiforme Treated with 15 MeV Fast Neutrons. Cancer, 49:2463-2465, 1982.
13. Chitwood, W.R., Jr., Meyers, W.C., Heaston, D.K., Herskovic, A.M.  McLeod, M.D. and Jones, R.S.  Diagnosis and Treatment of Primary Extrahepatic Bile Duct Tumors. American Journal of Surgery, 143:99-106, 1982.
14. Jones, R.S., Chitwood, W.R., Jr., Heaston, D.K. and  Herskovic, A.M.  The Combined Use of Percutaneous Transhepatic Drainage and Irradiation for Carcinoma of the Extrahepatic      Bile Ducts.  Contemporary Surgery, 22:59-64, 1983.
15. Engler, M.J., Herskovic, A.M., and Proimos, B.S.  Dosimetry of Rotational Photon Fields with Gravity-Oriented Eye Blocks. International Journal of Radiation Oncology Biology Physics, 10:431-438, 1984.
16. Herskovic, A.M., Cox, E.B., Fender, F., Schell, M., Henshaw, W., Rogers, C. and Ornitz, R.  Treatment Experience with 15 MeV Fast Neutrons in the Oral Cavity and Oropharynx.  Cancer, 53:2087-2090, 1984.
17. Orton, C.G. and Herskovic, A.M.  A Proposal for Universal Introduction of Lung Corrections. International Journal of Radiation Oncology Biology and Physics, 10:2383-2384, 1984.
18. Orton, C. G., Herskovic, A.M., Ezzell, G.A., Spicka, J.T. and Vitalis, T.  Transmission Blocks:  Clinical and Biological Rationales.  International Journal of  Radiation Oncology Biology and Physics, 11:2155-2158.
19.  Decker, D.A., V.L. Herskovic, A.M., and Cummings, G.D.  Brain  Metastases in Patients with Renal Cell Carcinoma:  Prognosis and Treatment.  Journal of Clinical Oncology, 1983.
20. Herskovic, A.M., Heaston, D.K. Engler, M.J. and Noell, K.T. Radical Radiotherapy for Bile Duct Carcinoma.  ECHO,(Endocurietherapy, Hyperthermia and Oncology) 1:119-124, 1985.
21. Herskovic, A.M., and Orton C.G. Elective Brain Irradiation for Small Cell Anaplastic Lung Cancer.  International Journal of Radiation Oncology Biology and  Physics, 12:427-429, 1986.
22. Herskovic, A.M., Ezzell, G.A., Orton, C.G., Lattin, P.B., Eisenbrey, A., Thoma, A., Lazo, A. and Muz, J.  Novel Applications of Phosphorus-32 in Treatment of Cystic Craniopharyngioma.  ECHO, Vol. 2, p. 2, 1986.
23. Cox. J.D., Sampson, M.K., Herskovic, A.M., Abrams, R. and Koehler, M.  Cisplatin and Etoposide Before Definitive Radiation Therapy for Inoperable Squamous Cell Carcinoma, Adenocarcinoma and Large Cell Carcinoma of the Lung: A Phase I/II Study of the Radiation Therapy Oncology Group.  Cancer Treatment Reports., 70(10):1219-1220, 1986.
24. Leichman, L., Herskovic, A.M., Leichman, C.G., Lattin, P.B., Steiger, Z., Tapazoglou, E., Rosenberg, J.C., Arbulu, A., Afaw, I. and Kenzie, J.  Non-operative Therapy for Squamous Cell Cancer of the Esophagus.  Journal of Clinical Oncology, 5(3):365-370, 1987.
25. Ezzell, G.A., Colin, C.G. Maughan, L., Spicka, J.T., Vitalis, J.T. and        Herskovic, A.M.  Practical Aspects of Transmission Cord Blocks in Radiotherapy.  American Association of Physics in Medicine 14(3):400-405, 1987.
26. Herskovic, A.M., Bauer, M., Seydel, H.G., Yesner, R.,   Doggett, R.L.S., Perez, C., Durbin, L. and Zinninger, M. Post Operative Thoracic Irradiation With or Without Levamisole in Non-Oat Cell Lung Cancer: The Results of Radiation Therapy Oncology Group Study.  International Journal of Radiation Oncology Biology and Physics, 14(1):37-42, 1988.
27. Seydel, H.G., Leichman, L., Byhardt, R., Cooper, J., Herskovic, A.M., Libnock, J., Pazdur, R., Speyer, J. and Tschan, J.  Preoperative Radiation and Chemotherapy for Localized Squamous Cell Carcinoma of the Esophagus: An RTOG Study.  International Journal of Radiation Oncology Biology and Physics, 14(1):33-35, 1988.
28. Herskovic, A.M., Leichman, L., Lattin, P., Ha, I., Leichman, C.G., Rosenberg, J., Steiger, Z., Bendall, C., Seyedsadr, M. and Vaitkevicius, V.  Chemo/Radiation With or Without Surgery in the Thoracic Esophagus: The Wayne State Experience.  International Journal Radiation Oncology  Biology  Physics, 15(3):655-662.
29. Emami, B., Perez, C.A., Herskovic, A.M. and Hederman, M.A. Phase I/II Study of Treatment of Locally Advanced (T3T4) Non-Oat Cell Lung Cancer with High Dose Radiotherapy (Rapid Fractionation).  International Journal of Radiation Oncology Biology and  Physics, 1988. 15-1021-5.
30. Herskovic, A.M., Ryan, J., Han, I., Lattin, P., Canady, A., Belenky, W., Phillipart, A., Binns, H. and Cushing, B.  Preliminary Report, Combined Interstitial and External Beam Radiation Therapy in Soft Tissue Tumors.  ECHO, Oct. 1988.
31. Herskovic, A.M., and Maughan, R.L.  A Quantitative Comparison of Two Spinal Cord Blocking Techniques.  Dosimetry.  Submitted for publication, 1988.
32. Ahmad, A., Kim, Y.H., Deppe, G., Malone, J. Herskovic, A.M., Ratanatharathorn, V., Medina, A., and Malviya, A.  Radiation Therapy in Stage II Carcinoma of the Endometrium.  Cancer, 63 (5):854-8 Mar 1 1989.
33. Ahmad, K., Kim, Y.H., Deppe, G., Malone, J., Malviya, V., Herskovic, A.M.  Ratanatharathorn, V. and Medina, A.  Stage III Carcinoma of the Endometrium.  European Journal of Gynecological Oncology 10(6) 383-9.
34. Bendell, C., Herskovic, A.M., Seyedsadr, M., Bioglin, K.E., Lattin, P.  Radiation-Induced Esophagitis.  The Assessment of Pain Relief Due to an Antacid with Lidocaine Mixture.  The Cancer Journal, 2:403-404, 1989.
35. Ahmad K., Kim Y.H., Deppe G., Malone J., Herskovic A.M., Ratanatharathorn V., Sakr WA, Medina A., Malviya V.  Results of treatment of locally advanced carcinoma of the endometrium Acta Oncologica 29(2) 203-9 1990.
36. Al Sarraf, M., Pajak T., Cooper M., Herskovic A.M., Ager, P:.J., Chemoradiotherapy in patients with locally advanced nasopharnygeal carcinoma a Radiation Therapy Oncology Group study. Journal of Clinical Oncology 8(8):1342-51 1990.
37. Ahmad K., Kim Y.H., Spitzer A., Gupta A., Han I., Herskovic A.M., Sakr, W.  Total Nodal Radiation in Progressive Sarcoidosis – Case Report. Am. J. Clinical Oncology (CCT) 15(4): pp.311-313, 1992.
38. Herskovic A.M., Orton C., Kraut M., Seyedsadr, M., Lattin P., Ahmad K., Han I., Han S., Holt J.,  Initial Experience with Practical Hyperfractionated Accelerated Radiotherapy Regimen. Int. Journal Radia. Oncol. Biol. Phys., Vol 21, pp 1275-1281. 1991.
39. Herskovic, A.M., Kraut M., Orton C., Byhardt R., Lattin P., Han S.  Experience with a Practical Hyperfractionated Accelerated Radiotherapy Regime.  Seminars in Radiation Oncology. Vol. 2. No 1 (January), 1992: pp 48-50.
40. Alehkteyar K., Herskovic A.M., Orton, C., Ryan, J., Lattin P., Ahmad K.,  Porter, A., Seyedsadr, M., Han I., Combined Brachytherapy and External Beam Radiotherapy in Soft-Tissue Tumors.  ECHO, April 1992.
41. Byhardt R., Pajak T., Emami B., Herskovic A.M., Doggett RS., Olson, L.  A Phase I/II Study to Evaluate Accelerated Fractionation via Concomitant Boost for Squamous Cell, Adeno and Large Cell Carcinomas of the Lung Report of the Radiation Therapy Oncology Group 8407.  Submitted International Journal of Radiation  Oncology Biology Physics.
42. Herskovic A.M., Martz K., Al Sarraf, M., Leichman L., Brindle J., Vaitkevius V., Cooper J., Byhardt R., Davis L., Emami, B.  Combined Chemotherapy and Radiotherapy Compared Radiotherapy in Patients with Cancer of the Esophageal.  New England Journal of Medicine 326:1593-1598   June 11, 1992.
43. William T. Sause, Thomas Pajak, Bahman Emami, Roger Byhardt, Arnold Herskovic.  The Radiation Therapy Oncology Group Experience Altered Fractionation in Lung Cancer.  Lung Cancer, Vol. 9, pp.229-238, 1993.
44. Graham, Mary V., M.D., Pajak, Thomas E., Ph.D., Herskovic, A.M., Emami, Bahman, M.D., Perez, Carlos A., M.D.  Phase I/II Study of Treatment of Locally Advanced (T3/T4) Non-Oat Cell Lung Cancer with Concomitant Boost Radiotherapy by the Radiation Therapy Oncology Group (RTOG 83-12):  Long-Term Results.  Int. J. Radiation Oncology Biology Physics Vol 31, No 4, pp. 819–825.  Sept. 28, 1994.
45. Ihn Han, M.D., PhD; Khurshid Ahmad, M.D.; Young Kim, M.D. John J. Feldmeier, D.O.; Gunter Deppe, M.D.; Vinay Malviyah, M.D.; John Malone, Jr., M.D.; Carl Christensen, M.D., PhD; Arnold Herskovic, M.D.; Vaneerat Ratanatharathorn, M.D.;  Arthur Porter, M.D.   Multifractionated Intravaginal High Dose Rate Brachytherapy in Gynecological Tumors.  ECHO Volume 10, Number 2, April 1994.
46. Laurie Gaspar, M.D.,  S. Nag, M.D., Arnold Herskovic, M.D., P. Matravadi, B. Speiser, M.D.   Consensus Guidelines for Brachytherapy of Esophageal Cancer. International Journal of Radiation Oncology, Biology, Physics.  38(1)127-32 1997.
47. E. Poplin, J. Jacobson, A. Herskovic, T. Panella, M. Valdivieso, L. Hutchins, M. MacDonald.  Evaluation of Multimodality Treatment of Locoregional Esophageal Carcinoma by Southwest Oncology Group 9060.  Cancer, Vol. 78, No. 9, pp. 1851-1856, November 1996.
48. M. Al-Sarraf, K. Martz, A. Herskovic, L. Leichman, J.S. Brindle, V.K. Vaitkevicius, J. Cooper, R. Byhardt, L. Davis, B. Emami.  Progress Report of Combined Chemoradiotherapy Versus Radiotherapy Alone in Patients with Esophageal Cancer:  An Intergroup Study.  Journal of Clinical Oncology, Vol. 15, No. 1, pp 227-284, January 1997.
49. Arnold Herskovic, M.D.,  Muhyi Al-Sarraf, M.D., Combination of 5-Fluorouracil and Radiaton in Esophageal Cancer. Seminars in Radiation Oncology.  Vol. 7, No.4, (October), 1997: pp. 1-10.
50. Gaspar LE,Qian C,Coia,LR,Herskovic A Graham,M: A Phase I/II Study of external Beam radiation brachytherapy and concurrent chemotherapy in localized cancer of the esophagus(RTOG 9207)  International Journal of Radiation Oncology, Biology,  Physics:37(3) 593-9 1997.
51. Poplin EA,JacobsonJ,Herskovic A Panella TJ Valdivieso M,Hutchins LF,Macdonald JS Evaluation of multimodality treatment of locoregional esophageal carcinoma by Southwest Oncology Group 9060 Cancer 78(9) 1851-6 1996.
52. Cooper J,Herskovic et al Long-term follow-up in patients with esophageal cancer treated with combined therapy Journal of American Medical Association 1999:281 (17) 1623-7.
53. Ali M, Kraut AM Valdiviesion M Herskovic A, et al Phase II Study of weekly alternating combination chemotherapy with concurrent hyperfractionated radiotherapy in limited stage lung cancer Cancer in press.
54. Herskovic A, Scott C, Demas W Et al Accelerated hyperfractionated for bronchogenic cancer Radiation Therapy Oncology Group 9205 American Journal of Clinical Oncology (in Press)
55. Herskovic A, Fisher J Orton B Lee CK,Chang JH,Sandhu T,Prysby,D,Scott,C Accelerated hyperfractionation in patients with non small cell bronchogenic cancers as a cost effective and user and patient friendly schedule in Cancer Investigation 18(6) 537-543 2000
56. Keller,Steve;M,SudeshnaAdak,HenryWagner,Arnold Herskovic,Ritsuko Komaki,Burke Brooks,Michael Perry,Robert Liningston,and David Johnson A Randomized Trial of Post Operative Adjuvant Therapy with Completely Resected Stage II and IIIa Non Small cell Lung cancer. New England Journal of Medicine vol 343:1217-1222 Oct 26,2000
57. Gaspar Laurie,Kathryn Winters,Walter Kocha;Wayne Pinover;Arnold Herskovic;Mary Graham;Leonard Gunderson;Observed function and weight change observed in phase I/Iistudy of external beam radiation and brachytherapy and concurrent chemotherapy in localized cancer of the esophagus RTOG 9207in The Cancer Journal ed DeVita,HellmanandRosenbergv7#5p388
58. Keller S,M Vangel Adak,S Wagner H;,Schiller A HERSKOVIC et al The influence of  gender on survival and tumor recurrence following adjuvant therapy of resected stage II and IIIA  Bronchogenic Lung Cancer LUNG CANCER 37 303-309
59. Keller S,M Vangel Adak,S Wagner H;,Schiller A HERSKOVIC et al. Second Tumors following adjuvant therapy for II and IIIA non small cell lung cancer. LUNG CANCER: 42; 79-86
60. Thomas,CR; Berkey,BA; Minsky,B; Gaspar,LE,Herskovic A;Rich;Gunderson LL-Recursive portioning Analysis of pretreatment Variables of 416 patients with locoregional esophageal cancer treated with definitive concomitant chemoradiation in Intergroup and RTOG Group Trials International Journal of Radiation Oncology Biology and Physics 2004 Apr 1 58 1405-10.
61. Gaspar,L E;Winter,K;Kocha WI Coia LR,Herskovic A;Graham,M A phase I/IIstudy of external beam radiation,brachytherapy….RTOG 9207 Cancer 2000 Mar 1 88(5) 988-95.
62. James Marsh, AM Herskovic, B Gielda,F Hughes, T Hoeppner, J Turian and R Abrams Intracranial metastasic Disease Spares the Limbic Circuit A Review of 697 metastatic Leisons in 107 Patients IJRBOP v76 p504

Submitted or in press:

James C marsh Shalini Garg, Julie Wendt, Benjamin Gielda,Arnold Herskovic Intracranial Metastasis Disease rarely Involves the pituitary: case report, retrospective analysis of 935 metastases in 155 patients and review of the literature

James c Marsh, Wesley Russell Benjamin Gielda Arnold Herskovic Do High Grade Astrocytomas areise from the neural Stem Cell Compartment? A retrospective Review of 99 cases

Review Article James CMarsh Benjamin Gielda,Arnold Herskovic, Ross Abrams Cognitive Sparing During the Administration of Whole Brain Radiotherapy and Prophylactic Cranial Irradiation Current Concept and Approaches- for Oncology

Review Article:: Update in the Treatment of Thoracic Esophageal cancer- Arnold Herskovic, Wesley Russell, Mary Joe Fiddler, Michael Liptay, Muhyi Al Saraaaf accepted in Annals of Oncology

ASTRO-Poster  2011 Treatment of Choroid Melanoma Shalini Garg,Wesley Russell, Arnold Herskovic

Submission ASCO Treatment of Ocular Adnexal Maltomas Wesley Russell, Stephanie Gregory, Arnold Herskovic

Abstracts/Presentations:

1. Everson, L., Hansen, J., Herskovic, A.M., et al.  Allogenic Bone Marrow Transplantation in a Patient with Myelofibrosis. Soc. Exper. Hematol, Autumn, 1975.
2. Chabora, B. McD., Lattin, P.B., Lois, M., Murphy, M.D. and Herskovic, A.M.  Whole Lung Irradiation in the Pediatric Age Group: Low Dose versus Conventional Fractionation with Multi-Drug Chemotherapy.  Proc. ASTR. Int. J. Radia. Oncol. Biol. Phys., Supp. 1, p. 72, 1976.
3. Herskovic, A.M., Lipsett, J. and George, F.W., III.        Empirical         Treatment of Myasthenia Gravis Without Thymomas.            Proc. ASTR. Int. J. Radia. Oncol. Biol. Phys., Supp. 1, p. 39, 1976.
4. Herskovic, A.M., Bouzaglou, A., Vasan, S. and George, F.W., III. Hodgkins Disease in a Country Hospital Population.  Proc. ASTR.  Int. J. Radia. Oncol. Biol. Phys., Supp. 1, p. 154, 1976.
5. Bouzaglou, A., Herskovic, A.M., and George, F.W. III.  Sellar and Parasellar Irradiation.  American Radium Society.  Int. J. Radia. Oncol. Biol. Phys., Supp. 1977.
6. Herskovic, A.M., Powers, D., Pegelow, C. and George, F.W., III. Sellar and Parasellar Irradiation.  American Radium Society.  Int. J. Radia. Oncol. Biol. Phys., Supp. 1977.
7. Herskovic, A.M., Lowell, I., Lipsett, J., Pitts, F., Davis,
8. R., Appuzzo, M., Wetner, J. and George F., III.   Hydroxyurea as an Adjuvant in the Radiotherapy of Malignant Glial Tumors. Proc. ASTR. Int. J. Radia. Oncol. Biol. Phys., Supp. 2, 2:65, 1977.
9. Herskovic, A.M., Lewinsky, B.S., Frey, H.S. and Fingerhut,      A.G. Is Intracavitary Radiation Necessary for Endometrial Adenocarcinoma?  Proc. ASTR. November, 1977.
10. Herskovic, A.M., Schaefflein, F. and George, F.W., III.  Ocular Doses in German Helmet Fields.  RSNA., 1977.
11. Herskovic, A.M., Padikal, T.N., and Lee, S.N.  The Use of Computerized Tomography in Interstitial Dosimetry.  Proc. ASTR.  Int. J. Radia. Oncol. Biol. Phys., 4:113, 1978.
12. Herskovic, A.M., Lee, S., Scheer, A., Ornitz, R.  Fast Neutron Experience:  Epidermoid Carcinoma of the Upper Aerodigestive Tract.  Proc. ASTR. Int. J. Radia. Oncol. Biol. Phys., Supp. 2, 5:33, 1979.
13. Herskovic, A.M.  Cancer of the Cervix: Treatment.  Med.          Phys.,Series      R500, 7:450, July/August, 1980.
14. Herskovic, A.M., Heaston, D., Engler, M.J. and Noell, K.T. Treatment of Primary Bile Duct Carcinoma.  Amer. J. Clin. Oncol., 5:140, 1982.
15. Heaston, D.K., Herskovic, A.M., Noell, K.T., Engler, M.J., Moore, A.V. and Mills, S.  Technical Consideration in Transcatheter 192-Iridium Placement. Proc. RSNA Scientific Program, Scientific Sessions.  P. 105, November 1982.
16. Orton, C.G., Spika, J., Herron, D., Herskovic, A.M. and Mondalek, P.  Lung Corrections in Photon Beam Treatment Planning:  Are We Ready?  AAPM. July, 1983.
17. Seydel, H.G., Francis, M., Cox, J., Doss, L., Herskovic, A.M.,Phillips, T., Urtasun, R. and Johnson, R.  Hyperfractionated Radiation Therapy in the Treatment of unresectable Non-Oat Cell Carcinoma of the Lung.  Preliminary     report of a RTOG Pilot Study. ASTR. September 1984.
18. Seydel, H.G., Bauer, M., Herskovic, A.M., Hanks, G., Urtasun, R. and Yesner, R.  Post Operative Radiation Therapy with Placebo or Levamisole Following Resection of Lung Cancer with Metastatic Lymph Nodes.  Amer. Soc. Therapy. Radiol.  Int. J. Radia. Oncol. Biol. Phys., 1985.
19. Herskovic, A.M., Leichman, L., Lattin, P., Seydel, H.G., Pazdur, R., Leichman, G., Rosenberg, J., Steiger, Z., Bendall, C. and Vaitkevicius, V.  Cancer of the Thoracic Esophagus.  Proc. RSNA Scientific Program, Scientific Sessions.  December 1987.
20. Wozniak, A., Herskovic, A.M., Steiger, Z., Kraut, M., Valdivieso M.  Treatment of Locally Advanced Non Small Cell Lung Cancer (NSCLC) with Infusional VP16 and Cisplatinum.  Proc. ASCO.  March 1988.
21. Valdivieso, M., Pazdur, R., Flaherty, L., Martino, S., Redman, B., Wozniak, A., Herskovic, A.M., Baker, L., Intensive Chemotherapy of Small Cell Lung Cancer with Weekly Ectoposide, Cyclophosphamide, Hydroxydaumomycin and Oncovin. Proc ASCO 1988.
22. Douglas, H., Stablein, D., Stemmerman, G., Herskovic, A.M, Arbuck, S., for GITSG Therapy of Locally Advanced Surgically Incurable Gastric Cancer with Post operative Chemotherapy of 5FU Adriamycin and Methyl lCCNU with and without External Beam Radiation.  Proc ASCO 1988. 22.
23. Wozniak, A., Kraut, M., Herskovic, A.M., Steiger, Z., Flaherty, L., Valdivieso, M.  Toxicity of continuous infusion (CI) cisplatin, (DDP) and VP-16 and concurrent radiation therapy (RT) in the treatment of locally advanced non-small cell lung cancer.  AACR Abstract, J. Clin. Oncol.
24. Valdivieso, M., Wozniak, A., Flaherty, L., Pazdur, R., Herskovic, A.M., Heilburn, L., Redman, B., Martino, S., Baker, L.  Increased Therapeutic Index of Weekly Chemotherapy for Small Cell Lung Cancer (SCLC).  ASCO Annual Meeting 1990.
25. Kraut, M., Wozniak, A., Herskovic, A.M., Lattin, P., Steiger, Z., Zingas A., Sakr, W., Valdivieso, M.  Treatment of Locally Advanced Non Small Cell Lung Cancer with Mitomycin, Ectoposide, and Cisplatin and concurrent Radiation Therapy. Proc ASCO 1991.
26. W. Curran, T. Pajak, W. Sause, Bahman Emami, A. Herskovic,  J. Cox, J. Cooper.   Comparison of RTOG and AJC Staging System for Bronchogenic Cancer.  Cancer, 1991.
27. Poplin, E., Khanuja, P.S., Kraut, M., Herskovic, A.M., Lattin, P.B., Cummings, G., Desai, T., Gaspar, L.E., Kinzie, J.L.,      Steiger, Z., Vaitkevicius, V.  Chemoradiotherapy of Esophageal Carcinoma.  Cancer 74:1217-24, 1994.
28. Herskovic, A.M., Martz, K., Al Sarraf, M., Leichman, L., Brindle J., Vaitkevicius, V., Cooper, J., Byhardt, R., Davis, L., Emami, B., Intergroup Esophageal Study Comparison of Radiotherapy to RadioChemotherapy Combination a phase III Trial.  Proc ASCO 1991.
29. Herskovic, A.M., Alekhteyar, K., Han, I., Lattin, P., Ryan, J., Sandhu, T., Vaitkevicius, V., Zalupski, M.  10 Year Experience of Treatment of Soft Tissue Tumors with Radiotherapy, With or Without Concomitant Surgery or Chemotherapy.  American Radium Society Annual Meeting. April 29 – May 3, 1995. Paris, France.
30. Poplin, E., Herskovic, A., Jacobson, J., Panella, T., MacDonald, J.  Evaluation of Multimodality Treatment of Locoregional Esophageal Carcinoma: SWOG 9060.  ASCO Meeting May 20-23, 1995.
31. Herskovic, Arnold, Farnan, Nancy, Deman, W., Gaspar, Laurie, Trotti, A.  Tolerance and Toxicity of T.I.D. Accelerated Hyperfractionation for Bronchogenic Cancer-RTOG 9205.  Presented at ASTRO 1995 Meeting.
32. Bahman Emami, Charles Scott, Roger Byhardt, Mary V. Graham, E. James Andras, Madhu John, Arnold Herskovic, Raul C. Urtasun, Sucha O. Asbell, Carlos S. Perez, James Cox.  The Value of Regional Nodal Radiotherapy (Dose/Volume) in the Treatment of Unresectable Non Small Cell Lung Cancer:  An RTOG Analysis. Draft #3/October 1, 1996.  Presented at ASTRO 1996.
33. Laurie Gaspar, M.D., Chunlin Qian, Ph.D., Walter I. Kocha, M.D., Lawrence R. Coia, M.D., Arnold Herskovic, M.D., Mary Graham, M.D.  A Phase I/II Study of External Beam Radiation, Brachytherapy and Concurrent Chemotherapy in Localized Cancer of the Esophagus (RTOG 9207): Preliminary Toxicity Report.  International Journal of Radiation Oncology, Biology, Physics.  Presented at American Society of Therapeutic Radiation Onoclogy (RTOG), Miami, Fl., October 1995. Int. J. Radiation Oncologyu Biol. Phys., Vol. 37, No 3, pp. 593-599, 1997.
34. Charles Scott, Ph.D., William T. Sause, M.D., Roger Byhardt, M.D., Victor Marcial, M.D., Thomas F. Pajak, Ph.D., Arnold Herskovic, M.D., James D. Cox, M.D.  Recursive Partitioning Analysis of 1592 Patients on Four Radiation Therapy Oncology Group Studies in Inoperable Non Small Cell Lung Cancer.  RTOG #1061.  Lung Cancer 17 Suppl. 1 (1997) S59-S74.

Protocols:

1996    -           Macular Degeneration.

1996    -           Recurrent Prostate Cancer Implantation. Treated 5 patients post external rt

1996    -           Super Duper – Field within a field B.I.D., for Bronchogenic and Head and Neck Cancer.

1997    -           Selection and Management of Patients with Esophageal Cancer (SAM).

1997    -           Phase II Evaluation of Accelerated Hyperfractionation Delivered as Twice Daily Synchronous Concomitant Boost for Bronchogenic Carcinoma.  RTOG 1002.

2010                Retrospective Review of HDR Brachytherapy for Prostate Cancer

2011                Cognitive Sparing Whole Brain Radiotherapy

2011                Retrospective Review of ocular maltomas

Patents:

1-Use of Faraday Cage to prevent electro-magnetic interference in LINAC Room.

2-Axtrahand transport devices

3- Novel Brachytherapy Applications

Protocols works in progress:

Use of TomoTherapy accelerator for total lymphoid irradiation total marrow irradiation and both

Prophylactic and post operative radiation using the tomoTherapy unit to relatively spare the limbic system including hippocampus, Circle of Willis and pituitary fossa

New form of spinal radiotherapy

Integrated chemo radiotherapy for selective lymphoma

Cooperative Group Development: past

1. Lung Committee (RTOG)
   • Subcommittee on the Use of the Lung Inhomogeneity Corrections.
2. Significant participation in:
   RTOG 7927    8501
   RTOG 8108     9205
   RTOG 8312     9105
   RTOG 8407     9207
   • RTOG representative (PI) for Adjuvant Intergroup Lung Protocol RTOG 9105.
   • Principle Investigator – 8501 Esophagus IG
   • Principle Investigator – Tolerance and Toxicity of T.I.D. Accelerated Hyperfractionation for Bronchogenic Cancer-RTOG 9205.
     • 9207 Esophagus Brachytherapy
     • Development of 1002 B.I.D. Field within Field Lung
     • 9105 prior 8907 Intergroup adjuvant lung
   • Lung Committee (SWOG) – Radiotherapy
   • Small Cell CA – SWOG 8269.
   • Metastatic Non-Oat Cell CA – Primary 8300.
   • Thymoma Protocol – 8490 – Coordinator.
   • Evaluation of Multimodality Treatment of Locoregional Esophageal Carcinoma: SWOG-9060.  Abstract.  (Poplin, Jacobson, Herskovic, Panella, Valdivieso, Barlogie, MacDonald.)
   • Gastrointestinal Committee (RTOG)
   • Intergroup Esophagus RTOG representative.
   • Multiple of other areas
   • Brachytherapy Committee
   • Pilot Protocol 9207 – Esophagus Brachytherapy Co-coordinator.
   • Endobronchial Protocol — HDR: Submitted, accepted in principle.
   • Esophagus: co PI LDR and HDR protocol.
   • Prostate Template Protocol: Did not pursue.  Not enough interest.
   • Sarcoma Interstitial — Co-Chairman: Submitted.
   • Uterine Cervical Carcinoma HDR. LDR proposed GOG and RTOG, to be discussed July 1993.

Areas of Interest:

1. Breast Cancer
   • Draft concept intended to improve cosmesis and decrease subcutaneous and skin reaction
   • Development of electron beam skin dose spoiling grid, in testing phase.
   • Preliminary work suggests with only 12 mev electrons a skin sparing advantage with dose homogeneity achieved at about 4-5 cm depth.  The intention is to determine if clinically useful.
   • Need to evaluate the use of high energy photons, if appropriate.
   • Breast oligometastasis low incidence probably 0.5 to 1.0 %
2. Bronchogenic cancer
   • Protocol in IRB for post operative RT for (T1),T2;N0 patients
   • Accelerated hyperfractionation – past papers still find it interesting need to redefine RT volumes, concept also may be useful for other sites.
   • Joiner Protocol suggest TID low dose per fraction 50 cGy, 1-2 weeks along with ctx can positively  improve response and  sensitize tumors
   • Trying to improve implants with absorbable mesh like Ethicon
   • Oligometastasis protocol crude draft
   • Need to integrate new biologics and chemotherapy
   • Transmission block-virtual published in past using cerrobend and have experience with approximately 250 pts-main purpose to decrease pulmonary dose.
3. Esophageal cancer- SAM: selection and management concept sheet
   • Oligometastasis general especially prostate protocol draft needs to be discussed
   • GU prostate another taxotere RT protocol for hormone refractory cancer
   • Esophagitis /mucositis /enteritis draft protocol for glutamine amino acid 30 gm per day draft stage for discussion
   • Physician disaster preparedness for presentation a survey of physicians regarding preparedness for a disaster expect to resubmit to Health Affairs with Ellen Cannon
   • Entrepreneurial –extrahand patient safety transport devices also preliminary work on universal pill splitter and some work for a pathology surgical specimen orientation device

Master projects per IRB please note RTOG protocols did not originate locally

09021602 Prospective Trial Prophylactic Cranial Irradiation and post resection for Oligometastatic cranial disease accepted waiting for funding and corrections

0912201 Do High Grade Astrocytomas arise from neural stem cells compartment retrospective review of 99 cases with James Marsh etc

08060905 phase 1,2 integrated chemo radiotherapy for non-Hodgkins Lymphoma-pending several versions and numbers

09080504-Choroidal melanomas treated with I 125 plaque therapy ongoing

09020601 natural history of primary CNS lymphomas

08121902 why do intracranial metastasis spare the limbic system with Jim Marsh

08092502 data base for intra cranial metastasis

08101501 retrospective review of patients treated with HDR therapy for prostate cancer

Protocol pending

Use of Brachytherapy with Kyphoplasty,  GI and vascular stents, various unique devices for potential treatment of various solid tumors such as breast, kidney, liver, prostate, meningiomas, and pelvic tumors